T-cell Immunoglobulin and ITIM Domain Contributes to CD8+ T-cell Immunosenescence
نویسندگان
چکیده
منابع مشابه
T‐cell Immunoglobulin and ITIM Domain Contributes to CD8+ T‐cell Immunosenescence
Aging is associated with immune dysfunction, especially T-cell defects, which result in increased susceptibility to various diseases. Previous studies showed that T cells from aged mice express multiple inhibitory receptors, providing evidence of the relationship between T-cell exhaustion and T-cell senescence. In this study, we showed that T-cell immunoglobulin and immunoreceptor tyrosine-base...
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Immunosenescence is a concept used to describe the age-associated deterioration of immune function, characterized by functional and phenotypic changes on both cellular and systemic levels [1,2]. Immunosenescence in elderly people is associated with an increased susceptibility to infectious diseases, impaired response to vaccinations, and increased incidence of cancer and autoimmunity [3-5]. Dur...
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ژورنال
عنوان ژورنال: Aging Cell
سال: 2018
ISSN: 1474-9718
DOI: 10.1111/acel.12716